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Mosquito Maven Takes Bites For Malaria Research

Filed by KOSU News in Health.
January 2, 2013

Most of us do everything possible to avoid mosquitoes. But one Italian researcher literally sacrifices her right arm to keep the lowly insects alive.

Chiara Adolina is studying a new malaria drug, and she needs the little suckers for her experiments. So she feeds them each day with her own blood.

She extends her arm into a mosquito cage to give the insects “breakfast.” Several dozen mosquitoes spread across her forearm and jam their proboscises into her skin. “Can you see how fat they become?” she says. “Look at that tummy.”

Adolina affectionately refers to her mosquitoes as “my girls.”

Only female mosquitoes transmit malaria, so she’s far more interested in the girls in her mosquito colony than the guys.

“The female mosquitoes bite because they need the proteins of blood to make the shell of their eggs,” she says. “So they’re pregnant ladies.”

Adolina raises the insects at the Shoklo Malaria Research Unit, a remote laboratory on the Thai-Myanmar border. A drug-resistant form of malaria is emerging in the region, and counterfeit malaria medicines are a problem.

She’s working with a drug that tries to kill the parasite inside people during an early stage of the infection — at a time when the person hasn’t yet shown signs of being sick. The goal is to stop the parasite from moving back and forth between humans and mosquitoes.

Here in the U.S., biologists at the Centers for Disease Control and Prevention also farm mosquitoes for their malaria research, including some nasty bugs that are resistant to insecticides.

What happens if Adolina doesn’t feed her girls? “They’ll die probably,” she says. “That’s why when you see mosquitoes, and they really want to bite you, it’s not because they’re hungry. They really need to lay the eggs, so they need that blood meal.”

While working in Britain a few years ago, Adolina fed her mosquitoes reheated rabbit’s blood from a blood bank. Here in Thailand, though, she has a type of mosquito that will only dine on live human blo

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“Mosquitoes in Asia are really, really difficult to rear,” she says. “Really delicate. Very spoiled. If you put them in a cage, they won’t mate.”

This means Adolina has to artificially inseminate each tiny female in the colony. “It’s very difficult. It takes lots of time,” she says.

Most of the mosquitoes on her arm now have dark, swollen bellies, but they are still trying to probe into her skin some more. “They feed maybe five minutes,” she says. “But some of them, they are just trying to find the capillary. They just go around, and it takes longer.”

A few minutes after the mosquitoes have filled themselves with Adolina’s blood, most of the bite marks on her skin have disappeared. She says her body has gotten used to the bites — they hardly itch any more.

All this, so that she can study these mosquitoes and the potentially deadly parasites inside them. [Copyright 2013 National Public Radio]

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